Table 3.

Summary of the literature on fibroma‐associated hypercalcemia in pregnancy

	Tarnawa et al. 20	Rahil et al. 21
Maternal age (years)	32	36
Gestational age at discovery	29 weeks	First month of pregnancy
Clinical presentation	Lethargy, nausea, vomiting, abdominal pain	Nausea, vomiting, abdominal pain, weight loss
Clinical course	33 5/7 weeks Aspiration pneumonia, intubation Admission to intensive care unit Spontaneous labor, vaginal delivery Postmyomectomy hemorrhage	34 weeks PPROM, emergency cesarean section Postoperative septic shock and hemorrhage Slight neurological impairment secondary to diffuse ischemic changes and hypoxic insult
Newborn	IUGR, no postnatal complications	No complications
Surgery	Myomectomy immediately after delivery	Myomectomy with cesarean section
Maximal Ca level (mmol/L)	5.2 (NR 2.1–2.63)	4.8 (NR 2.1–2.6)
PTH (pmol/L)	Undetectable	0.3 (NR 1.6–6.9)
PTHrP (pmol/L)	22 (NR < 2)	N/A
Treatment	Hydration, furosemide, pamidronate 15 h after delivery, dialysis	Calcitonin, dialysis
Fibroma characteristics	23 cm in diameter, benign pedunculated Histological proof of PTHrP expression	30 cm in diameter, calcifications, benign

Ca, calcium; IUGR, intrauterine growth restriction; N/A, not available; NR, normal range; PPROM, premature preterm rupture of membranes; PTH, parathyroid hormone; PTHrP, parathyroid hormone‐related protein.