Figure 2.

Enzyme asymmetries A_α for optimal proteome allocation solutions obtained in different scenarios. The figure shows the optimal solution in terms of the enzyme asymmetries as a function the diffusion constants D_X and D_P, and for different values of the inhibition constant, in the case of uncompetitive inhibition of P on the enzyme E_S (see Equation 1), Subplots on each column, labeled (A–D) correspond to the solution obtained for a different values of 1/K_I, whereas rows represents the different enzymes of the pathway. The darker color in the 1/K_I = 10 and 1/K_I = 30 subplot columns highlight the region in which [E_{S, 2}] = [E_{X, 1}] = 0, and the pathway is completely split between the two cell types. The color scale corresponds to the asymmetry value of the different enzymes.