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. 2012 Mar 23;10(1):23–34. doi: 10.1016/S1672-0229(11)60030-2

Figure 3.

Figure 3

The flow chart for mining functional gene modules associated with RA via constructing a SNP-SNP network by the PIA algorithm. A. Constructing a SNP-SNP network with the top 100 SNP pairs whose total scores are higher than the threshold. B. Extracting sub-networks involved in hub SNPs whose degree is more than 5. C. Mapping SNPs onto genes using a dbSNP database and performing GO enrichment analysis of gene modules obtained from sub-networks. A gene module is considered a functional gene module in which at least one significant GO term is included.