Figure 3.

Comparative analyses of mutation rates of EIGs. A. EIGs were equally classified into highly-, moderately- and lowly-expressed genes based on their expression levels (RPKM values). This classification scheme was also applied for the following figures. The mutation rates vary among genes expressed at different levels. The mutation rates of C→T, A→G, C→G and G→T exhibited remarkable increases when expression levels are elevated. B. The frequencies of the four major mutation types including C→T, A→G, C→G and G→T showed asymmetry between transcribed DNA strands and the non-transcribed counterparts.