Table 3.
Top matched ligands based on expression patterns in the consensus tree shown in Figure 5
| Matched ligands | Conserved KEGG pathway categories | Conserved KEGG subpathways |
|---|---|---|
| 70L/AIG/SLC | Cellular processes, human diseases, organismal system | Cell cycle, p53 signaling pathway, phagosome, Parkinson’s disease, Huntington’s disease |
| LPA/IFG | Cellular processes, human diseases | p53 signaling pathway, bacterial invasion of epithelial cells |
| GRH/FML | Cellular processes, environmental information processing, genetic information processing, Human diseases, metabolism, organismal system | Cell cycle, regulation of autophagy, Aminoacyl-tRNA biosynthesis, ribosome, RNA degradation, RNA polymerase, DNA replication, ubiquitin mediated proteolysis, Parkinson’s disease, Huntington’s disease, thyroid cancer, TCA cycle, oxidative phosphorylation, pyrimidine metabolism, glyoxylate and dicarboxylate metabolism |
| PGE/NPY | Cellular processes, immune system, metabolism, organismal system | Oocyte meiosis, cytosolic DNA-sensing pathway, Fc gamma R-mediated phagocytosis, TCA cycle, ubiquinone and other terpenoid-quinone biosynthesis, oxidative phosphorylation, pyrimidine metabolism, riboflavin metabolism, terpenoid backbone biosynthesis |
| IFB/S1P | Cellular processes, human diseases, immune system, organismal system | Cell cycle, oocyte meiosis, p53 signaling pathway, Parkinson’s disease, Huntington’s disease, bacterial invasion of epithelial cells, Fc gamma R-mediated phagocytosis |
| BOM/LB4 | Human diseases, organismal system | Colorectal cancer, Glioma, Cardiac muscle contraction |
| NEB/NGF | Environmental information processing, human diseases, organismal system | mTOR signaling pathway, Parkinson’s disease, Amyotrophic lateral sclerosis, Colorectal cancer, Glioma, Neurotrophin signaling pathway |
| TNF/CGS | Cellular processes, genetic information processing, human diseases, metabolism | Cell cycle, p53 signaling pathway, ribosome, DNA replication, mismatch repair, SNARE interactions in vesicular transport, Parkinson’s disease, bacterial invasion of epithelial cells, steroid biosynthesis, oxidative phosphorylation, glyoxylate and dicarboxylate metabolism |
| PAF/CPG | Environmental information processing, immune system, metabolism | RIG-I-like receptor signaling pathway, cytosolic DNA-sensing pathway, pyrimidine metabolism, cyanoamino acid metabolism, one carbon pool by folate, riboflavin metabolism |
| TER/BAF | Cellular processes, environmental information processing, genetic information processing, metabolism | Cell cycle, oocyte meiosis, p53 signaling pathway, endocytosis, aminoacyl-tRNA biosynthesis, RNA degradation, spliceosome, ubiquitin mediated proteolysis, TCA cycle, pentose phosphate pathway, cyanoamino acid metabolism |
| DIM/TGF | Environmental information processing, genetic information processing, human diseases, immune system, metabolism, organismal system | Aminoacyl-tRNA biosynthesis, ribosome, RNA polymerase, basal transcription factors, spliceosome, protein export, mismatch repair, bacterial invasion of epithelial cells, colorectal cancer, RIG-I-like receptor signaling pathway, cytosolic DNA-sensing pathway, B-cell receptor signaling pathway, TCA cycle, pentose phosphate pathway, steroid biosynthesis, oxidative phosphorylation |