Table 1. Recurrent neoantigens identified exclusively in the cohort showing clinical benefit with their associated HLA types.
Variants were manually reviewed in the Integrated Genomics Viewer (34).
| Patient | Gene | HLA | Neoantigen | |
|---|---|---|---|---|
| 1 | Pat117 | BMPER | A11:01 | CIKTCDNWNK |
| Pat123 | BMPER | A31:01 | CIKTCDNWNK | |
| 2 | Pat174 | CGB8 | C02:02 | SSSKAPLPSL |
| Pat88 | CGB2 | C16:01 | SSSKAPLPSL | |
| 3 | Pat132 | CLCN4 | C04:01 | FFATLVAAF |
| Pat132 | CLCN4 | A23:01 | FFATLVAAF | |
| Pat38 | CLCN4 | C02:02 | FFATLVAAF | |
| 4 | Pat132 | CLCN4 | C07:01 | SFFATLVAAF |
| Pat132 | CLCN4 | A23:01 | SFFATLVAAF | |
| Pat38 | CLCN4 | C07:01 | SFFATLVAAF | |
| 5 | Pat132 | CLCN4 | C07:01 | ATLVAAFTL |
| Pat138 | CLCN4 | B15:17 | ATLVAAFTL | |
| Pat38 | CLCN4 | C07:01 | ATLVAAFTL | |
| 6 | Pat132 | CLCN4 | B08:01 | TLWRSFFATL |
| Pat132 | CLCN4 | A23:01 | TLWRSFFATL | |
| Pat38 | CLCN4 | A02:01 | TLWRSFFATL | |
| 7 | Pat07 | CNTNAP5 | A01:01 | FSADIFFFF |
| Pat07 | CNTNAP5 | C07:02 | FSADIFFFF | |
| Pat07 | CNTNAP5 | C07:01 | FSADIFFFF | |
| Pat77 | CNTNAP5 | A24:02 | FSADIFFFF | |
| Pat77 | CNTNAP5 | A26:01 | FSADIFFFF | |
| Pat77 | CNTNAP5 | C12:03 | FSADIFFFF | |
| 8 | Pat07 | CNTNAP5 | B08:01 | FFFFKTTAL |
| Pat07 | CNTNAP5 | C07:02 | FFFFKTTAL | |
| Pat07 | CNTNAP5 | C07:01 | FFFFKTTAL | |
| Pat77 | CNTNAP5 | C01:02 | FFFFKTTAL | |
| Pat77 | CNTNAP5 | C12:03 | FFFFKTTAL | |
| 9 | Pat07 | CNTNAP5 | C07:02 | IFFFFKTTAL |
| Pat77 | CNTNAP5 | C12:03 | IFFFFKTTAL | |
| 10 | Pat132 | ERCC8 | A23:01 | CVFQSNFQEF |
| Pat38 | ERCC8 | C02:02 | CVFQSNFQEF | |
| Pat38 | ERCC8 | B15:17 | CVFQSNFQEF | |
| 11 | Pat132 | ERCC8 | A01:01 | FQSNFQEFY |
| Pat38 | ERCC8 | C02:02 | FQSNFQEFY | |
| 12 | Pat117 | FAM5B | A02:01 | FQDSALLQL |
| Pat117 | FAM5B | C07:01 | FQDSALLQL | |
| Pat117 | FAM5B | C02:02 | FQDSALLQL | |
| Pat123 | FAM5B | C04:01 | FQDSALLQL | |
| Pat123 | FAM5B | C02:02 | FQDSALLQL | |
| 13 | Pat117 | FAM5B | A02:01 | FQDSALLQLI |
| Pat117 | FAM5B | C02:02 | FQDSALLQLI | |
| Pat123 | FAM5B | C02:02 | FQDSALLQLI | |
| Pat123 | FAM5B | C04:01 | FQDSALLQLI | |
| 14 | Pat117 | FAM5B | C02:02 | YTQGFQDSAL |
| Pat123 | FAM5B | C02:02 | YTQGFQDSAL | |
| 15 | Pat21 | FAM83B | B08:01 | YARSCVPSL |
| Pat21 | FAM83B | C07:01 | YARSCVPSL | |
| Pat88 | FAM83B | C16:01 | YARSCVPSL | |
| Pat88 | FAM83B | B14:02 | YARSCVPSL | |
| 16 | Pat21 | FAM83B | C07:01 | YARSCVPSLF |
| Pat88 | FAM83B | C16:01 | YARSCVPSLF | |
| 17 | Pat105 | HSF5 | A02:01 | FVIGTEQAV |
| Pat174 | HSF5 | A02:01 | FVIGTEQAV | |
| 18 | Pat105 | HSF5 | C05:01 | GSDIMSFVI |
| Pat174 | HSF5 | C02:02 | GSDIMSFVI | |
| 19 | Pat138 | LATS2 | A32:01 | SLVETPNYI |
| Pat38 | LATS2 | A02:01 | SLVETPNYI | |
| 20 | Pat132 | LOX | A01:01 | HTQGLSPDCY |
| Pat38 | LOXL1 | B15:17 | HTQGLSPDCY | |
| 21 | Pat123 | MKLN1 | C02:02 | HSKNCCLYVF |
| Pat88 | MKLN1 | C16:01 | HSKNCCLYVF | |
| 22 | Pat21 | OR52N5 | A01:01 | LSPTLNPIVY |
| Pat49 | OR52N5 | A01:01 | LSPTLNPIVY | |
| 23 | Pat66 | TRBV5-1 | A01:01 | ISGHRSVFWY |
| Pat66 | TRBV5-1 | B58:01 | ISGHRSVFWY | |
| Pat174 | TRBV5-1 | A29:02 | ISGHRSVFWY | |
| 24 | Pat21 | UGT2B28 | C07:01 | FQYHSLNVI |
| Pat79 | UGT2B7 | A02:01 | FQYHSLNVI | |
| Pat79 | UGT2B7 | C02:02 | FQYHSLNVI | |
| 25 | Pat88 | ZIM3 | A03:01 | FIYKSDFVK |
| Pat38 | ZIM3 | A03:01 | FIYKSDFVK | |
| 26 | Pat38 | ZIM3 | B15:17 | KSDFVKHQRI |
| Pat88 | ZIM3 | C08:02 | KSDFVKHQRI | |
| 27 | Pat38 | ZIM3 | B15:17 | KAFIYKSDFV |
| Pat88 | ZIM3 | C16:01 | KAFIYKSDFV | |
| 28 | Pat88 | ZNF229 | A29:02 | RVHTGEKLY |
| Pat38 | ZNF235 | B15:17 | RVHTGEKLY |