Figure 1. URAT1 inhibitors inhibit human URAT1 at substantially higher potency.

Dose response curves of benzbromarone (a), sulfinpyrazone (b), probenecid (c), and lesinurad (d) against human URAT1 (open symbols) and rat URAT1 (closed symbols). Data are from a single experiment and are representative of multiple experiments. Points represent the mean ± standard error of the mean (SEM) from triplicate samples. The potencies (half maximal inhibitor concentration values) are shown in Supplementary Table 1. For all inhibitors, the differences in potency between human URAT1 and rat URAT1 are statistically significant (P < 0.0001).