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. 2016 Oct 7;7:366. doi: 10.3389/fphar.2016.00366

FIGURE 3.

FIGURE 3

The degradation profiles of vicagrel (A), 2-oxo-clopidogrel (B) and production profiles of 2-oxo-clopidogrel from vicagrel (C) in the intestinal microsomes from rat, dog and human (The reactions were conducted in pH 7.4 Tris buffer at 37°C and initiated by the addition of vicagrel with a final concentration at 10 μM; The line marked in red represented the profiles in dog).