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Hepatic Hydrolysis of 2-oxo-clopidogrel in hepatic microsomes from rats, dogs and human.
| λ (h-1) | t1/2 (h-1) | Clinvitro (L⋅h-1⋅g protein-1) | Clint (L⋅h-1⋅kg-1) | |
|---|---|---|---|---|
| Rat | 0.640 ± 0.035 | 1.09 ± 0.06∗ | 1.280 ± 0.069 | 2.304 ± 0.125 |
| Dog | 0.520 ± 0.035 | 1.34 ± 0.09 | 1.036 ± 0.066 | 1.498 ± 0.100 |
| Human | 0.244 ± 0.036 | 2.88 ± 0.42 | 1.220 ± 0.181 | 1.412 ± 0.209 |
∗p < 0.05, rat vs. dog or human.
