Table 5.
The production velocity of CAM from 2-oxo-clopidogrel in the plasma, intestinal and hepatic microsomes from rats, dogs, and human.
| Rats | Dogs | Human | ||
|---|---|---|---|---|
| Production velocity (pmol/min/mg protein) | ||||
| Intestine | 5 μM | – | – | – |
| 50 μM | – | – | – | |
| Plasma | 5 μM | 11.05 ± 0.55 | – | – |
| 50 μM | 34.65 ± 0.68 | – | – | |
| Liver | 5 μM | 1.78 ± 0.63 | 7.55 ± 0.68∗ | 4.14 ± 0.78 |
| 50 μM | 35.13 ± 3.34 | 67.13 ± 7.56∗ | 43.88 ± 2.56 | |
–The parameters were not calculated, because there was no CAM produced in the plasma of dogs or human, or the intestinal microsomes of rats, dogs and human. ∗p < 0.05, rat vs. dog.