Table 6.
Kinetics of AM production from 2-oxo-clopidogrel in the intestinal and hepatic microsomes from rats, dogs, and human.
| Intestine | Km (μM) | Vmax (pmol/min/mg protein) | Clinvitro (ml⋅h-1⋅g protein-1) | Clint (ml⋅h-1⋅kg-1) |
|---|---|---|---|---|
| Rat | 14.57 ± 1.242 | 3.102 ± 0.08735 | 12.77 ± 1.039 | 0.766 ± 0.0623 |
| Dog | 3.023 ± 0.3466 | 2.489 ± 0.1154 | 49.40 ± 15.68∗ | 3.26 ± 1.034∗ |
| Human | 4.661 ± 1.436 | 1.344 ± 0.1179 | 17.30 ± 4.414 | 0.571 ± 0.132 |
| Liver | Km (μM) | Vmax (pmol/min/mg protein) | Clinvitro (L⋅h-1⋅g protein-1) | Clint (L⋅h-1⋅kg-1) |
| Rat | 40.71 ± 4.510 | 203.4 ± 7.241 | 0.270 ± 0.0136 | 0.486 ± 0.025 |
| Dog | 9.392 ± 1.194 | 48.68 ± 1.842 | 0.315 ± 0.0399 | 0.453 ± 0.058 |
| Human | 17.58 ± 3.294 | 66.29 ± 2.494 | 0.233 ± 0.0489 | 0.269 ± 0.058 |
∗p < 0.05, dog vs. rat or human.