Fig. 3.

Effects of regional lung aeration and pneumonia on drug concentration in lungs. a Relationship of lung aeration (%) to pulmonary concentration of amikacin (μg/g) for different routes of administration. b Relationship of route of drug administration to pulmonary concentration of amikacin (μg/g) for different severities of pneumonia. Pulmonary concentrations derived from homogenized lung tissue specimens measured by an immunoenzymatic method. Figure derived from Elman et al. [47]