Table 3.
Predicted canonical pathways affected in the colonic explants harvested from the weaned piglets and subjected to ex‐vivo incubation for 6 h.
| Canonical pathway | Genes affected | ‐log (P‐value) | Z‐score |
|---|---|---|---|
| NF‐κB signalling | 21/172 | 3·07E01 | −3·578 |
| Dendritic cell maturation | 19/178 | 2·65E01 | −2·982 |
| Toll like receptor signalling | 18/74 | 1·09E32 | −1·941 |
| NGF signalling | 8/113 | 9·66E00 | −2·646 |
| TREM1 signalling | 19/76 | 3·41E01 | −2·524 |
| Production of nitric oxide and reactive oxygen species in macrophages | 14/186 | 1·72E01 | −2·496 |
| Lymphotoxin β receptor signalling | 7/56 | 1·03E01 | −2·449 |
| IL‐17A signalling | 9/66 | 1·35E01 | −2·333 |
| RANK signalling | 9/89 | 1·22E01 | −2·333 |
| Role of pattern recognition receptors in recognition of bacteria and viruses | 20/125 | 3·16E01 | −2·324 |
| MIF regulation of innate immunity | 8/44 | 1·31E01 | −2·121 |
| PI3K signalling | 7/132 | 7·62E00 | +1·890 |
NF‐κB = nuclear factor kappa B; IL = interleukin; RANK = receptor activator of nuclear factor κB; PI3K = phosphatidylinositol 3‐kinase; MIF = migration inhibitory factor; TREM = triggering receptor expressed on myeloid cells 1; NGF = nerve growth factor.