Table 6.
Predicted canonical pathways affected in the colonic explants harvested from the weaned piglets and subjected to ex‐vivo incubation for 3 h in the presence of lipopolysaccharide (LPS) or LPS and dexamethasone combined.
| LPS | LPS+ dexamethasone | |||||
|---|---|---|---|---|---|---|
| Canonical pathway | Genes affected | ‐log (P‐value) | Z‐score | Genes affected | ‐log (P‐value) | Z‐score |
| HMGB1 signalling | 9/120 | 1·35E01 | +2·333 | 11/120 | 1·75E01 | −3·317 |
| IL‐17F in inflammatory diseases | 6/44 | 1·06E01 | +2·236 | 7/44 | 1·29E01 | −2·449 |
| Dendritic cell maturation | 8/177 | 1·02E01 | +2·121 | 12/177 | 1·76E01 | −3·464 |
| IL‐8 signalling | 4/184 | 3·99E00 | +2·000 | 7/184 | 1·56E01 | −3·162 |
| IL‐6 signalling | 7/116 | 9·83E00 | +1·890 | 10/116 | 8·42E00 | −2·449 |
| Acute‐phase response signalling | 6/169 | 7·07E00 | +1·633 | 9/169 | 1·21E01 | −3·000 |
| Activation of IRF by cytosolic pattern recognition receptors | 5/62 | 7·73E00 | +1·342 | 8/62 | 1·39E01 | −1·414 |
| TREM1 signalling | 10/75 | 1·76E01 | +1·265 | 8/75 | 1·33E01 | −2·828 |
| TNFR1 signalling | 4/49 | 6·28E00 | +1·000 | 5/49 | 8·26E00 | −2·236 |
| Toll‐like receptor signalling | 9/74 | 1·55E01 | +1·342 | 10/74 | 1·77E01 | −1·890 |
| LPS/IL‐1 mediated inhibition of RXR function | 4/221 | 3·69E00 | +1·000 | 6/221 | 6·39E00 | −2·236 |
| Pattern recognition receptors | 12/125 | 1·95E01 | +0·707 | 12/125 | 1·95E01 | −2·828 |
| Production of nitric oxide and reactive oxygen species | 6/180 | 6·91E00 | ‐ | 8/180 | 1·01E01 | −2·121 |
| PPAR signalling | 6/93 | 8·63E00 | −1·633 | 7/93 | 1·05E01 | −2·646 |
| NF‐κB signalling | 10/172 | 1·39E01 | −0·632 | 8/172 | 1·03E01 | −2·121 |
| LXR/RXR activation | 6/121 | 7·94E01 | −0·816 | 8/121 | 1·15E01 | +2·121 |
HMGB1 = high mobility group box 1 protein; IL = interleukin; TREM1 = triggering receptor expressed on myeloid cells 1; TNFR1 = tumour necrosis factor receptor 1; PPAR = peroxisome proliferator‐activated receptors; NF‐κB = nuclear factor kappa B.