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. 2016 Oct 6;16:773. doi: 10.1186/s12885-016-2796-x

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Phosphorylation of EGFR Y845 is reduced with IGF-1R specific inhibitor picropodophyllin (PPP). a Representative western blot of EGFR Y845 show decreased levels in response to 0.5 μM concentration PPP with time in both resistant cells (left panel) and in sensitive cells (right panel) The inhibitory effect of PPP is more rapid in resistant as compared to sensitive cells. b similar treatment times as in (a), but monitored effect using 10 μM AG1024, another inhibitor of IGF-1R. Note that AG1024 is less inhibitory to IGF1R than PPP