Table 4.

Multivariable analysis to identify independent risk factors for reintubation at 72 h and 7 days postextubation, and for death at 90 days postextubation, in patients with chronic obstructive pulmonary disease

	Cough peak flow ≤ 70 L/minute		Cough peak flow > 70 L/minute
	OR (95 % CI)	p Value	OR (95 % CI)	p Value
Reintubation at 72 h postextubation
Use of NIV	0.11 (0.03–0.38)	<0.01	–	N/A
Intubation period before extubation, days	1.10 (1.01–1.09)	0.03	–	N/A
Reintubation at 7 days postextubation
Use of NIV	0.27 (0.10–0.77)	0.01	–	N/A
Cough peak flow, L/minute	0.95 (0.92–0.98)	<0.01	–	N/A
Death at 90 days postextubation
Use of NIV	0.27 (0.10–0.74)	0.01	–	N/A
Hemoglobin, g/dl	0.98 (0.95–1.00)	0.02	0.97 (0.93–1.00)	0.05
Cough peak flow, L/minute	0.97 (0.94–1.00)	0.03	–	N/A
APACHE II score at extubation	1.21 (1.01–1.46)	0.04	1.46 (1.03–2.07)	0.04

NIV Noninvasive ventilation, APACHE II Acute Physiology and Chronic Health Evaluation II, N/A Not applicable

We entered age, sex, APACHE II score, intubation periods, cough peak flow, hemoglobin, secretions, suction frequency, Glasgow Coma Scale score, heart rate, respiratory rate, rapid shallow breathing index, arterial blood gas tests, and use of NIV into multivariable analysis to identify independent risk factors for reintubation at 72 h and 7 days postextubation, and for death at 90 days postextubation