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. 2016 Oct 7;10:230. doi: 10.3389/fncel.2016.00230

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Copyright © 2016 Vastagh, Rodolosse, Solymosi and Liposits.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overview of gene expression changes in the elements of postsynaptic signaling cascades. Pathway analysis revealed significant activation of a REACTOME pathway called' Neurotransmitter Receptor Binding and Downstream Transmission in the Postsynaptic Cell' (Bonferroni, p = 3.37E-06). Genes that are involved in the various neurotransmitter systems are hierarchically clustered according to their strength of interconnectivity and perturbance level. Clusters were identified as follows: 1. AMPA receptor complex; 2. NMDA receptor complex; 3. Acetylcholine-gated receptor complex; 4. G-proteins; 5. GABA (B) receptor; 6. GABA (A) receptor.