Table 2.
Change in main outcomes compared to baseline within and between groups
| Testosterone group n = 49 |
Placebo group n = 51 |
Difference between groupsa | P valueb | |
|---|---|---|---|---|
| Fat mass, kg | ||||
| Week 0–10 | –7.9 (–9.7 to –6.1)* | –7.5 (–9.4 to –5.7)* | –0.4 (–3.0 to 2.2) | 0.78 |
| Week 0–56 | –9.4 (–11.3 to –7.5)* | –6.5 (–8.5 to –4.5)* | –2.9 (–5.7 to –0.2) | 0.04 |
| Fat mass, % | ||||
| Week 0–10 | –3.8 (–4.9 to –2.6)* | –3.0 (–4.3 to –1.8)* | –0.7 (–2.4 to 1.0) | 0.40 |
| Week 0–56 | –5.7 (–6.9 to –4.5)* | –2.9 (–4.3 to –1.6)* | –2.8 (–4.6 to –1.0) | 0.003 |
| Lean mass, kg | ||||
| Week 0–10 | –3.9 (–5.3 to –2.6)* | –4.8 (–6.2 to –3.5)* | 0.9 (–1.0 to 2.8) | 0.36 |
| Week 0–56 | –0.6 (–2.0 to 0.8) | –4.0 (–5.5 to –2.5)* | 3.4 (1.3 to 5.5) | 0.002 |
| VAT area, mm2 | ||||
| Week 0–10 | –7688 (–9333 to –6044)* | –6590 (–8267 to –4912)* | –1099 (–3448 to 1251) | 0.36 |
| Week 0–56 | –7223 (–8921 to –5526)* | –4545 (–6383 to –2708)* | –2678 (–5180 to –176) | 0.04 |
| Body weight, kg | ||||
| Week 0–10 | –12.0 (–14.5 to –9.5)* | –13.5 (–16.0 to –11.0)* | 1.5 (–2.0 to 5.1) | 0.40 |
| Week 0–56 | –11.4 (–13.9 to –8.8)* | –10.9 (–13.6 to –8.1)* | –0.5 (–4.3 to 3.3) | 0.80 |
Data are mean (95 % CI)
aDifference between groups (mean adjusted difference) refers to the change over time across groups (linear mixed effects model)
b P value refers to the overall significance of the change between groups during follow-up
* P < 0.05 within group
VAT visceral abdominal tissue