Table 2.
The top ten functions enriched for the differentially expressed genes
| GO ID | Description | Gene number | p value | Gene symbols |
|---|---|---|---|---|
| (A) | ||||
| GO:0006366 | Transcription from RNA polymerase II promoter | 47 | 1.01E−03 | SOX21, TCF25, TOP2A, GTF2F2, CIAO1, SERPINE1, DKK1, CYR61, SOX18, PAF1… |
| GO:0007010 | Cytoskeleton organization | 32 | 2.76E−04 | PTK2, DPYSL2, CNN3, BICD2, CLIC4, CTGF, EDN1, NRAS, ITGB1, RHOG… |
| GO:0006897 | Endocytosis | 23 | 2.57E−05 | PTK2, PIK3R2, THBS1, SERPINE1, DKK1, CYFIP2, AXL, RABEPK, LRP1B, ABCA1… |
| GO:0071375 | Cellular response to peptide hormone stimulus | 15 | 5.75E−04 | PTK2, PIK3R2, GNG10, PPM1A, GNG5, PIK3R1, ATP6V1G1, NRAS, SOCS2, GNG12… |
| GO:0000398 | mRNA splicing, via spliceosome | 10 | 1.02E−02 | PABPC1, GTF2F2, LSM7, LSM3, POLR2C, UPF3B, MBNL2, C1QBP, PRPF31, PAPOLA |
| GO:0048469 | Cell maturation | 9 | 8.96E−04 | SOX18, AXL, GJA1, DLD, FOXO3,TYMS,CLN5,EPAS1,PTBP3 |
| GO:0043200 | Response to amino acid stimulus | 7 | 6.71E−04 | CTGF, EDN1, CEBPB, TYMS, CCL2, LAMTOR3, LAMTOR1 |
| GO:0006112 | Energy reserve metabolic process | 7 | 4.38E−02 | GNG10, GNG5, GFPT2, RAP1B, PPP1CC, GNG12, PYGB |
| GO:0018279 | Protein N-linked glycosylation via asparagine | 6 | 1.02E−02 | UGGT1, MLEC, GFPT2, B4GALT5, PGM3, STT3B |
| GO:0006261 | DNA-dependent DNA replication | 6 | 1.49E−02 | POLB, MCM3, RFC5, TOP2A, BAZ1A, RPAIN |
| (B) | ||||
| GO:0007167 | Enzyme-linked receptor protein signaling pathway | 19 | 2.89E−03 | KANK1, RTN4, ATP6V1D, PTPRK, EEF2K, ERRFI1, CGN, TGFBR2, ATP6V0A1, MVP… |
| GO:0043588 | Skin development | 9 | 4.97E−03 | PTHLH, ALDH3A2, ERRFI1, YAP1, STK4, EMP1, COL5A2, NCOA3, DICER1 |
| GO:0030330 | DNA damage response, signal transduction by p53 class mediator | 7 | 1.41E−04 | NDRG1, SPRED1, PSME3, CDKN1A, E2F7, CASP2, HIPK2 |
| GO:0001890 | Placenta development | 7 | 4.74E−04 | TXNRD1, ADM, CCNF, SPP1, STK4, NDP, E2F7 |
| GO:0031100 | Organ regeneration | 5 | 6.05E−05 | ADM, TGFBR2, CCND1, LCP1, CDKN1A |
| GO:0071456 | Cellular response to hypoxia | 5 | 2.26E−03 | HMOX1, NPEPPS, NDRG1, BNIP3, HIPK2 |
| GO:0048002 | Antigen processing and presentation of peptide antigen | 5 | 4.35E−02 | CTSD, NPEPPS, PSME3, AP1S1, AP1S2 |
| GO:0055093 | Response to hyperoxia | 4 | 2.97E−05 | TXNRD1, BNIP3, CAV1, CDKN1A |
| GO:0000188 | Inactivation of MAPK activity | 4 | 1.36E−04 | DUSP5, SPRED1, CAV1, DUSP22 |
| GO:0060443 | Mammary gland morphogenesis | 4 | 2.15E−03 | PTHLH, TGFBR2, CAV1, NCOA3 |
GO Gene Ontology, ID identification
(A) The top ten functions enriched for the up-regulated genes. (B) The top ten functions enriched for the down-regulated genes