Table 3.
The pathways enriched for the differentially expressed genes
| KEGG ID | Name | Gene number | p value | Gene symbols |
|---|---|---|---|---|
| (A) | ||||
| 4062 | Chemokine signaling pathway | 12 | 1.63E−03 | PTK2, PIK3R2, GNG10, GNG5, RAP1B, PIK3R1, NRAS, IL8, GNG12, CSK, FOXO3, CCL2 |
| 4510 | Focal adhesion | 11 | 7.54E−03 | PTK2, PIK3R2, THBS1, THBS2, RAP1B, PPP1CC, PIK3R1, ITGB1, ACTG1, FLNB, CAV2 |
| 4810 | Regulation of actin cytoskeleton | 11 | 1.18E−02 | PTK2, PIK3R2, CYFIP2, PPP1CC, PIK3R1, NRAS, ITGB1, GNG12, ACTG1, CSK, ARHGEF6 |
| 4910 | Insulin signaling pathway | 9 | 5.22E−03 | PIK3R2, PPP1CC, PIK3R1, NRAS, SOCS2, PTPN1, PYGB, CALM2, PTPRF |
| 3013 | RNA transport | 9 | 9.27E−03 | PABPC1, EIF3A, NUP54, EIF3G, UPF3B, NUP155, KPNB1, NUP37, EIF2S3 |
| 4145 | Phagosome | 8 | 2.82E−02 | TAP1, THBS1, THBS2, ATP6V1G1, ITGB1, ACTG1, LAMP2, DYNC1LI2 |
| 5100 | Bacterial invasion of epithelial cells | 7 | 1.24E−03 | PTK2, PIK3R2, PIK3R1, ITGB1, RHOG, ACTG1, CAV2 |
| 5142 | Chagas disease (American trypanosomiasis) | 7 | 1.13E−02 | PIK3R2, SERPINE1, GNA11, PIK3R1, IL8, IFNGR1, CCL2 |
| 4722 | Neurotrophin signaling pathway | 7 | 3.05E−02 | PIK3R2, RAP1B, PIK3R1, NRAS, CALM2, CSK, FOXO3 |
| 4360 | Axon guidance | 7 | 3.28E−02 | PTK2, DPYSL2, SEMA4F, NRAS, ITGB1, SLIT2, EFNA1 |
| 5131 | Shigellosis | 6 | 3.01E−03 | ITGB1, IL8, RHOG, ACTG1, FBXW11, CSK |
| 5211 | Renal cell carcinoma | 5 | 2.45E−02 | PIK3R2, RAP1B, PIK3R1, NRAS, EPAS1 |
| 5412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 5 | 3.03E−02 | ITGB1, DAG1, GJA1, ACTG1, CDH2 |
| 5410 | Hypertrophic cardiomyopathy | 5 | 4.62E−02 | TPM3, ITGB1, DAG1, TPM1, ACTG1 |
| 4350 | TGF-beta signaling pathway | 5 | 4.83E−02 | THBS1, THBS2, SMAD6, ID3, SMAD5 |
| 20 | Citrate cycle (TCA cycle) | 4 | 5.11E−03 | CS, DLD, DLAT, SDHA |
| 5144 | Malaria | 4 | 3.19E−02 | THBS1, THBS2, IL8, CCL2 |
| 5213 | Endometrial cancer | 4 | 3.39E−02 | PIK3R2, PIK3R1, NRAS, FOXO3 |
| 5223 | Non-small cell lung cancer | 4 | 3.82E−02 | PIK3R2, PIK3R1, NRAS, FOXO3 |
| 3410 | Base excision repair | 3 | 4.23E−02 | POLB, PARP1, PARP3 |
| (B) | ||||
| 4144 | Endocytosis | 9 | 4.62E−04 | ASAP2, VPS36, TGFBR2, ASAP1, CAV1, SH3KBP1, EHD1, RAB22A, DNM3 |
| 4142 | Lysosome | 7 | 4.55E−04 | CTSD, TPP1, ATP6V0A1, ABCB9, AP1S1, AP1S2, NEU1 |
| 2010 | ABC transporters | 4 | 1.58E−03 | ABCC2, ABCC3, ABCB9, ABCC5 |
| 10 | Glycolysis/gluconeogenesis | 4 | 6.56E−03 | ENO2, ALDH3A2, PGAM1, PGK1 |
| 5220 | Chronic myeloid leukemia | 4 | 9.85E−03 | TGFBR2, CCND1, CDKN1A, BCL2L1 |
| 561 | Glycerolipid metabolism | 3 | 1.98E−02 | ALDH3A2, AGPAT9, LCLAT1 |
| 5212 | Pancreatic cancer | 3 | 4.69E−02 | TGFBR2, CCND1, BCL2L1 |
| 4966 | Collecting duct acid secretion | 2 | 3.85E−02 | ATP6V1D, ATP6V0A1 |
| 650 | Butanoate metabolism | 2 | 4.67E−02 | AKR1B10, HMGCS1 |
(A) The pathways enriched for the up-regulated genes. (B) The pathways enriched for the down-regulated genes. Kyoto Encyclopedia of Genes and Genomes, KEGG; identification, ID