Table 3. Cox regression analysis for the prognostic value of PAK1, pERK and nuclear β-catenin on OS and RFS in lung cancer patients.
| OS |
RFS |
|||||||
|---|---|---|---|---|---|---|---|---|
| Case No. | HR* | 95% CI | P | Case No. | HR* | 95% CI | P | |
| PAK1 | ||||||||
| Low | 46 | 1 | 46 | 1 | ||||
| High | 41 | 2.22 | 1.28–3.85 | 0.004 | 41 | 1.69 | 1.04–2.73 | 0.033 |
| pERK | ||||||||
| Low | 30 | 1 | 30 | 1 | ||||
| High | 57 | 2.94 | 1.53–5.63 | 0.001 | 57 | 1.77 | 1.02–3.09 | 0.043 |
| Nuclear β-catenin | ||||||||
| Low | 45 | 1 | 45 | 1 | ||||
| High | 42 | 2.29 | 1.26–4.16 | 0.007 | 42 | 1.84 | 1.12–3.04 | 0.017 |
| PAK1/pERK | ||||||||
| Low/Low | 20 | 1 | 20 | 1 | ||||
| High/Low | 10 | 0.95 | 0.33–2.79 | 0.928 | 10 | 1.43 | 0.57–3.56 | 0.442 |
| Low/High | 26 | 1.74 | 0.76–4.02 | 0.193 | 26 | 1.53 | 0.75–3.14 | 0.244 |
| High/High | 31 | 4.72 | 2.18–10.2 | <0.001 | 31 | 2.42 | 1.23–4.76 | 0.011 |
| pERK/ nuclear β-catenin | ||||||||
| Low/Low | 29 | 1 | 29 | 1 | ||||
| High/Low | 16 | 2.06 | 0.83–5.12 | 0.12 | 16 | 1.75 | 0.78–3.91 | 0.174 |
| Low/High | 17 | 2.00 | 0.78–5.12 | 0.149 | 17 | 1.95 | 0.87–4.40 | 0.107 |
| High/High | 25 | 3.29 | 1.61–6.72 | 0.001 | 25 | 2.39 | 1.28–4.45 | 0.006 |
OS: overall survival; HR: Hazard ratio; RFS: relapse free survival.
*HR for all cases was adjusted by age, gender, smoking status and stage.