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. Author manuscript; available in PMC: 2016 Oct 7.
Published in final edited form as: J Immunol Methods. 2014 Dec 15;417:34–44. doi: 10.1016/j.jim.2014.12.004

Figure 5. Fc and Fab regions have different glycosylation patterns.

Figure 5

IgG was isolated from 125 human donors and analyzed using the described technique, including Fc and Fab separation. Structures were summed to make groups as described in Table 2 and plotted (A). Friedman paired ANOVA was performed to assess differences **** = p < 0.0001 among all groups. Sensitivity of detection of Fc (B) and Fab (C) fragments was determined as for intact IgG in Figure 1.