Figure 6.

Rho-associated protein kinase inhibitor Y27632 increases outflow in mouse eyes. Eyes treated with Y27632 were perfused with 200 μM drug in BSS for 30 minutes at 15 mm Hg, followed by a 15 minutes of perfusion at 5 mm Hg before measuring outflow (Protocol A). Control eyes were treated identically except for the absence of drug. The lines of fit for the linear part of the plots are: Control, y = 0.0047x + 0.0175, R² = 0.99946; Y27632, y = 0.0082x + 0.0003, R² = 0.9996. C was different between groups: control, C = 4.7 ± 1.2 nL/min/mm Hg (whole eye C = 10.4 ± 2.64 nL/min/mm Hg); Y27632, C = 8.2 ± 3 nL/min/mm Hg (whole eye C= 18.04 ± 6.6 nL/min/mm Hg). C = mean ± SD. SEM is shown for data points in the graph.