Table 3.
Vaccination effect of normal rats with pcDNA-CCOL2A1 vaccine at the maximum doses of 3 mg/kg on serum biochemistry rountine parameters on 2nd week after vaccination (n = 6, ± s)
| Parameters | Vaccine | Control | |
|---|---|---|---|
| GLU(mmol/L) | 8.02±2.30 | 10.71±5.42 | |
| Renal function | BUN(mmol/L) | 8.91±1.14 | 9.19±1.38 |
| Cre(μmol/L) | 37.58±7.47 | 42.17±9.29 | |
| UA(μmol/L) | 317.67±82.74 | 278.5±93.10 | |
| Liver function | ALT(IU/L) | 75.17±34.53 | 57.83±9.20 |
| TP(g/L) | 80.52±3.24 | 77.30±4.78 | |
| Albumin(g/L) | 33.42±3.25 | 30.93±3.10 | |
| Glubulin(g/L) | 47.10±5.15 | 46.37±2.40 | |
| TBIL(μmol/L) | 2.82±0.46 | 3.13±0.80 | |
| DBIL(μmol/L) | 0.57±0.33 | 0.47±0.18 | |
| TBA(μmol/L) | 26.10±9.29 | 16.66±3.40 | |
| Heart function | ALP(IU/L) | 344.50±130.96 | 291.8±105.36 |
| AST(mmol/L) | 252.17±127.47 | 197.17±64.40 | |
| Blood lipids | triglyceride(mmol/L) | 2.79±1.03 | 3.53±0.94 |
| TC(mmol/L) | 2.07±0.11 | 1.92±0.09 | |
| HDL(mmol/L) | 1.52±0.13 | 1.36±0.05 | |
| LDL(mmol/L) | 0.21±0.07 | 0.20±0.07 |
Parameters are listed in SI units; GLU: blood glucose; BUN: blood urea nitrogen; Cre: creatinine; UA: uric acid; ALT: alanine aminotransferase; TP: total protein; TBIL: total bilirubin; DBIL: direct bilirubin; TBA: total bile acid; ALP: alkaline phosphatase; AST: aspartate aminotransferase; TC: total cholesterol. HDL: high-density lipoprotein; LDL: low-density lipoprotein.
*P < 0.05 compared with control. These data are representative of 3 experiments. Three separate experiments yielded similar results.