Figure 2.

Immunization with RSV L19 formulated in nanoemulsion generates cross-protective neutralizing antibodies. (A) Serum neutralizing antibody titers against RSV L19 were determined at 0, 4, 5, and 21 weeks. Neutralizing titers are determined as the serum dilution which neutralizes 50% of virus. Results are presented as mean titer ± standard deviation (n = 8 cotton rats per group). Neutralizing antibody titers against both L19 and A2 virus were determined after the final immunization and prior to viral challenge in animals immunized with (B) W₈₀5EC or (C) P188. Points represent neutralization titer for individual animals. Error bars indicate standard deviation.