Table I.

South African pMTCT Guidelines Between 2008 and 2013

	National Department of Health (2008)	Clinical Guidelines (2010)	National Department of Health (2013)
Gestation at initiation	28 weeks	14 weeks	Any
Regimen during pregnancy	AZT monotherapy	AZT monotherapy	Fixed Dose Combination(FDC) – FTC/TDF/EFV
Regimen during labor	sd NVP at onset of labor Continue with AZT 3hrly until delivery	sd NVP at onset of labor Continue with AZT 3hrly until delivery	Continue FTC/TDF/EFV
Post delivery	Stop all ARV's	Stat dose of Truvada (TDF and FTC)	Continue FTC/TDF/EFV
Postpartum period	No continuation during postpartum period	No continuation during postpartum period	Continue FDC for one week after cessation of breastfeeding
Infant regimen	sd NVP and AZT(for 7 or 28 days*)	NVP for 6 weeks or for duration of breastfeeding	Eligible to start HAART
Cd4 cutoff for initiation of HAART	≤200 c/μl	≤350 c/μl	≤350 c/μl