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. 2015 Mar 19;85(4):267–277. doi: 10.1111/tan.12543

Figure 4.

TAN-12543-FIG-0004-b

(A) Expression of MIR155HG in matched and mismatched bidirectional mixed lymphocyte cultures (MLCs) at 72 h. (B) Expression of MIR155HG in mismatched MLCs at 24 h, 48 h, 72 h and 6 days. (C) Verification of microRNA‐155 (miR‐155) induction in further mismatched MLCs at three time points (72 h, day 6 and day 7) and correlation to MIR155HG expression, Pearson's correlation is shown. (D) Fold change expression of MIR155HG and miR‐155 in mismatched MLC in the presence of neutralising antibody to interferon‐gamma (IFNγ) or isotype control. Gene expression is shown as fold change in the MLC vs the mean expression of the individuals. (E) Expression of miR‐155, MIR155HG and IDO1 in human peripheral blood mononuclear cell (PBMC) treated with 10 ng/ml of human recombinant IFNγ for 24 h. Fold changes relative to control of untreated PBMC. Cumulative data of three separate experiments; * P ≤ 0.05.