Table 2.

Downregulated genes in matched vs mismatched MLC ^a

Gene symbol	S2 − (S5 + S6) mismatched		S3 − (S4 + S6) mismatched		S1 − (S4 + S5) matched
	FC	Corrected P	FC	Corrected P	FC	Corrected P
SEPP1	−17.20	0.0036	−15.23	0.0009	1.03	1.0020
F13A1	−8.89	0.0003	−15.95	0.00001	1.06	1.0117
RNASE1	−7.81	0.1433	−19.80	0.0366	−1.02	1.0045
FOS	−7.72	0.0101	−10.77	0.0073	−6.18	0.4073
LGMN	−5.96	0.0108	−7.38	0.0074	−1.14	0.5846
LGMN	−5.54	0.0066	−6.85	0.0030	−1.22	0.4033
DUSP1	−5.47	0.0157	−4.59	0.0327	−3.99	0.5231
FOSB	−5.08	0.0551	−3.79	0.0956	−5.70	0.5291
ADORA3	−4.83	0.0047	−6.53	0.0072	1.05	1.0130
HS3ST2	−4.61	0.0723	−5.33	0.0441	−1.14	0.8104
CHST13	−4.50	0.0029	−5.66	0.0019	−1.05	0.9255

ANOVA, analysis of variance; MLC, mixed lymphocyte culture.

^aGenes found to be downregulated more than fivefold in mismatched MLCs in the microarray study together with corresponding fold change values in the matched MLC presented for comparison. Genes with significantly altered expressions were identified by one‐way anova with Benjamini–Hochberg multiple testing correction, with P < 0.01 and were passed on for the fold change analysis. For a given gene its change in expression was calculated by subtracting its average normalised intensity in individuals from the normalised intensity in MLCs (P < 0.01).