. 2015 Oct 2;122(1):61–70. doi: 10.1002/cncr.29686

Table 2.

Univariate and Multivariate Analyses of Prognostic Factors for Survival in the Full Cohort of 419 Patients With Mass‐Forming–Dominant Intrahepatic Cholangiocarcinoma

		Univariate Analysis			Multivariate Analysis
Variable	No. of Patients	5‐Year Survival Rate, %	MST, mo	P	HR (95% CI)	P
Tumor size, cm
≤2	27	82.4	ND	.011^a	2.487 (0.912‐6.780)	.075
>2	392	40	29
No. of tumors
Solitary	316	53.5	ND	< .001^a	2.570 (1.814‐3.643)	< .001^a
Multiple	103	ND	15.2
Portal vein invasion
Absent	210	52.1	ND	.009^a
Present	209	34.2	25.5
Hepatic vein invasion
Absent	300	46.1	36.6	.007^a
Present	119	ND	19.4
Arterial invasion
Absent	386	44.9	36.6	.003^a
Present	33	ND	16.6
Biliary invasion
Absent	192	44.9	43.5	.07
Present	227	ND	26.2
Major biliary invasion
Absent	344	46.5	36.6	.004^a
Present	75	ND	20.3
Serosal invasion
Absent	258	48.3	43.5	.001^a
Present	161	35.2	21.4
Lymph node metastasis
Negative	267	58.4	ND	< .001^a	2.818 (1.992–3.987)	< .001^a
Positive	152	11.1	16.0
Distant metastasis
Negative	412	44.2	34.7	< .001^a	2.940 (1.258–6.869)	.01^a
Positive	7	0	4.2

Abbreviations: CI, confidence interval; HR, hazard ratio; MST, medial survival time; ND, not determined.

This P value indicates a statistically significant difference.