Table 1.
Estimated regression coefficients from mixed effects repeated measures models to show the effect of cancer stage on outcome
| Time × cancer stage interaction P‐value | Cancer stage | |||
|---|---|---|---|---|
| Model coefficienta | 95% CI | P‐value | ||
| EORTC dimension | ||||
| HRQoL/global health | 0.823 | −13.4 | (−30.9, 4.0) | 0.124 |
| Physical function | 0.761 | −5.2 | (−18.4, 8.0) | 0.420 |
| Role function | 0.598 | −1.1 | (−22.6, 20.3) | 0.912 |
| Emotional function | 0.764 | −10.5 | (−34.3, 13.2) | 0.362 |
| Cognitive function | 0.790 | 0.9 | (−15.9, 17.7) | 0.912 |
| Social function | 0.729 | −4.4 | (−16.2, 25.0) | 0.661 |
| Fatigue | 0.472 | 5.0 | (−10.8, 20.9) | 0.513 |
| Nausea | 0.878 | −4.6 | (−13.3, 4.1) | 0.283 |
| Pain | 0.663 | −14.2 | (−38.8, 10.4) | 0.240 |
| Dyspnoea | 0.222 | 2.1 | (18.8, 14.5) | 0.791 |
| Insomnia | 0.406 | 7.8 | (−14.0, 29.6) | 0.462 |
| Appetite loss | 0.847 | 11.7 | (−11.9, 35.4) | 0.320 |
| Constipation | 0.891 | −6.9 | (−4.9, 18.6) | 0.242 |
| Diarrhoea | 0.916 | 0.8 | (−9.4, 11.0) | 0.873 |
| Financial | 0.216 | 7.7 | (−5.2, 20.5) | 0.224 |
| SF36 dimension | ||||
| Physical functioning | 0.559 | −2.2 | (−17.7, 13.2) | 0.765 |
| Role physical | 0.248 | 3.6 | (−31.9, 39.2) | 0.832 |
| Bodily pain | 0.227 | −4.6 | (−25.0, 15.9) | 0.644 |
| General health | 0.083 | 4.1 | (−8.8, 16.9) | 0.518 |
| Vitality | 0.482 | −0.8 | (−19.3, 17.7) | 0.930 |
| Social functioning | 0.821 | −12.4 | (−34.4, 9.7) | 0.253 |
| Role emotional | 0.659 | −15.7 | (−44.7, 13.3) | 0.266 |
| Mental health | 0.053 | −19.3 | (−37.2, −1.3) | 0.037 |
| EPAQ dimension | ||||
| Urinary pain | 0.930 | 5.9 | (−1.9. 13.8) | 0.127 |
| Voiding | 0.919 | −4.5 | (−10.7, 1.6) | 0.139 |
| Overactive bladder | 0.473 | 4.4 | (−8.5, 17.4) | 0.974 |
| Stress incontinence | 0.603 | −0.2 | (−9.4, 9.0) | 0.962 |
| Urinary HRQoL | 0.996 | 2.9 | (−9.9, 15.7) | 0.632 |
| Irritable bowel | 0.999 | −1.0 | (−9.0, 6.9) | 0.785 |
| Constipation | 0.714 | −3.2 | (−17.5, 11.1) | 0.643 |
| Evacuation | 0.329 | −3.2 | (−8.4, 2.1) | 0.221 |
| Bowel continence | 0.196 | 2.2 | (−4.3, 8.7) | 0.491 |
| Bowel HRQoL | 0.625 | −1.1 | (−10.1, 7.8) | 0.789 |
| Vaginal pain and sensation | 0.927 | −6.6 | (−22.0, 8.9) | 0.379 |
| Vaginal capacity | 0.283 | −5.9 | (33.5, 21.8) | 0.654 |
| Prolapse | 0.951 | −0.9 | (−4.3, 2.4) | 0.524 |
| Vaginal HRQoL | 0.543 | −5.0 | (−16.4, 6.4) | 0.356 |
| Sexual urinary | 0.490 | −2.6 | (−16.0, 10.8) | 0.660 |
| Sexual vaginal | 0.482 | −14.2 | (−35.2, 6.8) | 0.154 |
| Dyspareunia | 0.265 | −0.5 | (−41.3 40.3) | 0.962 |
| General sex life | 0.208 | −1.5 | (−16.0, 13.1) | 0.825 |
a
Coefficient for stage from repeated measures model, positive value indicates higher score.