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. 2016 Oct 3;9:5999–6008. doi: 10.2147/OTT.S109342

Figure 3.

Figure 3

Infliximab inhibits CC cells’ viability via ADCC and CDC effects.

Notes: ADCC and CDC effects were reflected by the reduction in the cell viability of CC cell lines HCT116 and HT29 cultured with effector cells (macrophage) or active complement with infliximab treatment. (A and B) In the control group, with the increase in infliximab concentration, neither HCT116 cell line nor HT29 cell line had an apparent reduction in cell viability. This suggested that there was no direct cytotoxicity of infliximab on CC cell lines. However, with the presence of effector cells and complement, infliximab decreased CC cells’ viability significantly with the increasing dose. *P<0.05.

Abbreviations: CC, colon cancer; ADCC, antibody-dependent cellular cytotoxicity; CDC, complement-dependent cytotoxicity.