Table 2.
32 full-factorial design layout of simvastatin RDTs
| Formulation # | Variables
|
Responses*
|
||||
|---|---|---|---|---|---|---|
| Croscarmellose sodium (%) X1 | Hardness (kP) X2 | Disintegration time (seconds) | Q15min§ | Q30min§ | Water absorption ratio | |
| 1 | 1 | 1 | 6.43 | 26.52 | 40.94 | 129.1 |
| 2 | 1 | 3 | 52.45 | 30.2 | 39.47 | 84.5 |
| 3 | 1 | 5 | 63.72 | 29.54 | 43.76 | 69.2 |
| 4 | 2 | 1 | 4.98 | 40.85 | 48.51 | 124.8 |
| 5 | 2 | 3 | 45.65 | 39.45 | 52.47 | 75.8 |
| 6 | 2 | 5 | 52.23 | 36.47 | 48.96 | 72.3 |
| 7 | 3 | 1 | 5.06 | 48.12 | 59.74 | 139.5 |
| 8 | 3 | 3 | 39.19 | 45.98 | 56.19 | 102.7 |
| 9 | 3 | 5 | 47.43 | 42.51 | 57.57 | 83.6 |
| Check point | 2.4 | 1 | 5.82 | 25.64 | 51.61 | 124.7 |
Notes:
*
Standard deviation values of the responses did not exceed 5% of the measured values.
§
Q15min and Q30min are percentages of drug dissolved after 15 and 30 minutes, respectively.
Abbreviation: RDT, rapid disintegrating tablet.