Figure 2.

The influence of ICV injection of urocortin 3 on central splice variants of acyl ghrelin-induced hyperphagia in freely fed satiated rats.

Notes: After ICV injection of urocortin 3 (1 or 2 nmol/rat) or vehicle, O-n-octanoylated ghrelin or des-Gln¹⁴-ghrelin was ICV injected immediately, and cumulative food intake was measured at 1, 2, 4, 8, 12, and 24 hours. The results are shown in (A–F), respectively. Data are presented as mean ± SEM. ^*P<0.05, ^**P<0.01, ^***P<0.001, compared to the vehicle-injected group; ^#P<0.05, compared between groups with and without urocortin 3 injection; n=12 rats in each group.

Abbreviations: ICV, intracerebroventricular; SEM, standard error of the mean.