Figure 6.
The influence of ICV injection of corticotropin-releasing factor receptor 2 antagonist, astressin2-B, on central urocortin 3 counteracting acyl ghrelin-induced acceleration of gastric emptying in conscious, fasted rats.
Notes: In 16-hour food-deprived rats, after injection of either astressin2-B (3 nmol/rat) or saline, urocortin 3 (0.3 nmol/rat) or vehicle was injected immediately and followed with infusion of two variants of acyl-ghrelin. Fifteen minutes after ICV injection, a nonnutrient semiliquid test meal was catheter-gavaged. Thirty minutes later, radioactivity was measured and gastric emptying was calculated. Data are presented as mean ± SEM. ***P<0.001, compared between groups with and without urocortin 3 injection; ###P<0.001, compared between groups with and without astressin2-B injection; n=8 rats in each group.
Abbreviations: ICV, intracerebroventricular; SEM, standard error of the mean.