Table 2.
Summary of results from the psychophysiological interaction (PPI) analysis in a priori regions using a seed-based approach with the amygdala or hippocampus. Clusters shown survived correction (α ≤ 0.05) within a priori search regions of the prefrontal cortex or amygdala/hippocampus complex. Peak coordinates (x, y, z) are based on the MNI atlas in LPI orientation. The statistical model included childhood adversity (A), adolescent internalizing (I), and their interaction term (A X I). BA = Brodmann area, amyg = amygdala, hipp = hippocampus, dm/dlPFC = dorsomedial/dorsolateral prefrontal cortex.
| Contrast | Seed | Effect | Cluster | BA | k | t | x | y | z |
|---|---|---|---|---|---|---|---|---|---|
| Negative-neutral | L amygdala | I | R amygdala | -- | 39 | −3.40 | 26 | −6 | −26 |
| R amygdala | A | B mPFC | 9,10 | 699 | 3.29 | −2 | 58 | 2 | |
| R amygdala | A X I | B dmPFC | 9,10 | 333 | −2.92 | 0 | 52 | 18 | |
| L hippocampus | A | B dm/dlPFC | 8,9 | 480 | 2.82 | 2 | 42 | 50 | |
| R hippocampus | A | L dm/dlPFC | 8,9,32 | 1054 | 2.66 | 0 | 38 | 58 | |
| R hippocampus | A | R dm/dlPFC | 8,9 | 939 | 3.76 | 20 | 46 | 42 | |
| Positive-neutral | No significant effects | ||||||||