Table 2.
Mean parameter estimates (90% confidence intervals) and derived PKPD indices (IC20, IC70 and IC80)
| Cisapride | Moxifloxacin | Sotalol | |
|---|---|---|---|
| I0 (%) | 98.1 (96.5–99.7) | 94.0 (90.9–97.2) | 99.7 (97.9–101.6) |
| Imax (%) | 99.5 (96.0–103.0) | 104 (94.0–114.5) | 103 (100.3–106.3) |
| IC50 (μM) | 0.1 (0.086–0.12) | 1030 (752–1466) | 56.4 (50.4–63.2) |
| IC20 (μM) | 0.02 | 160.68 | 13.32 |
| IC70 (μM) | 0.22 | 1649.88 | 117.18 |
| IC80 (μM) | 0.36 | 2543.77 | 190.81 |
Data (n = 3 for each experimental point) from the equilibrium [3H]‐dofetilide binding displacement assay was analysed using an Imax model. I0 represents the percentage [3H]‐dofetilide binding in the absence of a competing molecule. IC20, IC70 and IC80 are the inhibitory concentrations associated with 20, 70 and 80% binding, respectively.