Figure 2.
BPs, heart rate, QA interval and CBT measured continuously for 24 h using radiotelemetry in conscious rats. Rats were treated with vehicle or baclofen at 3, 10 and 30 mg·kg−1, p.o. in an ascending dose paradigm. Dashed line indicates time of compound administration at 0, 4 and 8 h. Panels show effects of vehicle, baclofen, p.o. on: (A) systolic BP; (B) diastolic BP; (C) mean arterial BP (MAP) (D) pulse pressure; (E) heart rate; (F) core body temperature. Data points correspond to means ± SEM. Significant changes in responses are denoted by * P < 0.05, baclofen from vehicle.