Figure 4.

Schematic of different PKPD models used to fit the baclofen‐mediated cardiovascular response. Haemodynamic model utilized in analysis of the data. Model 1 assumes baclofen acts on TPR alone. Model 2 assumes site of action is HR alone. Model 3 assumes drug effect on SV alone. Model 4 allows for drug effect on all endpoints simultaneously. An effect compartment is included to account for differences from plasma exposure at each of the endpoints individually.