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. 2016 Oct 8;22:1156–1168.

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Copyright © 2016 Molecular Vision.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited, used for non-commercial purposes, and is not altered or transformed.

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Proinflammatory cytokines decreased the expression of RPE characteristic genes in an RPE cell culture system established from adult human donor eyes. The cultured cells were treated with the cytokines (interferon gamma (IFN-γ), 100 u/ml + tumor necrosis factor alpha (TNF-α), 10 ng/ml + interleukin-1 beta (IL-1β), 10 ng/ml) for 20 h under serum-free conditions. Real-time PCR analysis of the expression of mRNAs for RDH5, RDH10, MITF, and RPE65 is shown. *p<0.05 when compared to respective control, n = 4.