Table 1.

Targeted somatic mutation (TSM) profiles of mutations occurring at motifs of key deaminases associated with somatic mutagenesis for 194 high‐grade serous ovarian adenocarcinoma (HGS‐OvCa) exome samples

Deaminasefamily	Keymotif	Mutationtype	Mutated Codon Target Site (5′ to 3′)			SignificanceP‐value
			MC1	MC2	MC3
AID	WRCG	C>A	7	17	17
		C>G	17	16	34	1.54E‐97
		C>T	138	59	141
	CGYW	G>A	58	150	69
G>C	7	16	21	2.60E‐93
		G>T	11	15	13
APOBEC3G	CCG	C>A	20	10	20
		C>G	26	12	23	1.52E‐110
		C>T	172	69	130
	CGG	G>A	88	142	136
		G>C	22	27	16	3.58E‐88
		G>T	18	16	24
APOBEC3B	TCG	C>A	17	3	28
		C>G	26	12	11	1.77E‐48
		C>T	90	42	83
	CGA	G>A	135	81	44
		G>C	16	12	7	3.14E‐82
		G>T	27	18	7
ADAR	WAY	A>C	27	58	21
		A>G	110	191	71	4.46E‐61
		A>T	59	81	47

For each motif, the preferred target sites are in bold. In the motifs defined, W = A/T, R  =  A/G, and Y = T/C. MC1, MC2, and MC3 refer to the position of the mutations within the mutated codon (MC), read 5‐prime (5′) to 3‐prime (3′). The Chi square level of statistical significance for deviation from the expected distribution of mutations in a 3 × 3 TSM table by type of mutation (×3) and location within the MC (×3) for each motif is shown in the right hand column (P < 0.001, 8 df). The mutation data used to produce Table 1 are shown in the Table S2.). AID, activation‐induced cytidine deaminase; ADAR, adenosine deaminase; MC, mutated codon.