Table 2.

Table of targeted somatic mutation (TSM) targets for motifs associated with ADAR and AID deaminase activity to demonstrate how targeting preferences are changed when the 5‐prime and 3‐prime nuclear context is altered for 194 high‐grade serous ovarian adenocarcinoma (HGS‐OvCa) tumors

DeaminaseEnzyme	TargetMotif	PreferredMutation	Target codonPosition	Sig. Level(P value)
ADARs	RAWA	A>T	MC1	1.37E‐09
	CWA	A>G	MC2	5.21E‐55
	GWA	A>G	MC3	9.02E‐17
	AWA	A>G	MC1	6.10E‐17
	AWG	A>G	MC2	1.91E‐47
	AWT	A>G	MC3	3.44E‐05
AID	WRCGS	C>T	MC1	5.00E‐67
	XWRCT	C>G	MC1	5.63E‐09
	WRCAW	C>T	MC3	2.90E‐12
	WGGYW	G>T	MC1	4.77E‐08
	SCGYW	G>A	MC2	1.13E‐91
	STGYW	G>A	MC3	4.83E‐15

W = A/T, S = C/G, R = A/G, Y = T/C and X = C/A. MC1, MC2, and MC3 refer to the position of the mutations within the mutated codon (MC), read 5‐prime (5′) to 3‐prime (3′). The Chi square level of statistical significance for deviation from the expected distribution of mutations in a 3 × 3 TSM table by type of mutation (×3) and location within the MC (×3) for each motif is shown in the right hand column (P < 0.001, 8 df). AID, activation‐induced cytidine deaminase; ADAR, adenosine deaminase.