Skip to main content
. 2016 Sep 12;36(5):2633–2640. doi: 10.3892/or.2016.5085

Figure 1.

Figure 1

Overexpression of MPS1 in pediatric brain tumors. (A) Microarray expression of MPS1 mRNA in 90 pediatric brain tumors showed significant overexpression of MPS1 in high-grade pediatric brain tumors when compared to normal brain. Error bars represent standard error of the mean (SEM). (B) Microarray expression of MPS1 mRNA in 120 patients with medulloblastoma demonstrated that MPS1 mRNA is significantly elevated in medulloblas-toma compared to adult and fetal cerebellum but not significantly different among the genomic subgroups (WNT, SHH, groups 3 and 4). Error bars represent SEM. (C) MPS1 protein expression in patient tumor samples including two group 3 and two group 4 samples compared to normal pediatric cerebellum (CB). (D) MPS1 protein expression in commonly used medulloblastoma cell lines (D283, D458 and D425, group 3 genomic subgroup; Daoy, ONS-76 and UW228, Shh genomic subgroup). ATRT, atypical teratoid/rhabdoid tumor: GMB, glioblastoma multiforme; MED, medulloblastoma; PA, pilocytic astrocytoma.