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Chemical inhibition of MPS1 in medulloblastoma induces cell cycle arrest. (A) NMS-P715 induced G2/M arrest in medulloblastoma cells. Representative flow plots with quantification of cell cycle fractions. (B) Western blot analysis of cell cycle-related proteins upon MPS1 inhibition with NMS-P715. MPS1 inhibition resulted in decreased cyclin B2 as well as decreased CDC2 protein levels in the Daoy and D425 cells, but not in the D458 cells.
