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Silencing MARCH1 inhibits the Wnt/β-catenin pathway. (A) The Wnt pathway-targeted genes decreased at mRNA level in MARCH1-silenced cells. (B) TOP-flash luciferase reporter results showed that silencing MARCH1 downregulated the Wnt/β-catenin pathway. (C) Silencing MARCH1 inhibited β-catenin protein expression and (D) attenuated the translocation of β-catenin into the nucleus. (E) E-cadherin protein expression was enhanced in MARCH1 silenced cells; *p<0.05 vs. the NC or mock group.
