Table I.
The ten most significant differential expression pathways and genes between KD and NC.
| Gene set name | Pathway analysis
|
||
|---|---|---|---|
| No. of genes | P-value | Gene names | |
| KEGG_PATHWAYS_IN_CANCER | 26 | 4.36E-08 | RB1, ABL1, CDK6, SKP2, CBL, CBLB, PIK3R1, RAC1, AKT3, ITGA6, FN1, LAMB2, MAX, RUNX1, MAPK8, MMP2, FGF2, FGF5, FGF14, LEF1, TCF7, WNT5A, FZD6, RALA, GLI2, MMP1 |
| KEGG_CELL_CYCLE | 12 | 3.78E-04 | RB1, ABL1, CDK6, SKP2, CDC25B, MCM2, MCM3, MCM4, CDC20, ESPL1, E2F4, RBL2 |
| KEGG_ENDOCYTOSIS | 14 | 3.78E-04 | CBL, CBLB, PIP5K1C, PIP5K1A, AP2M1, AP2A1, EEA1, SMURF2, NEDD4, PARD6B, ACAP3, LDLRAP1, LDLR, VPS36 |
| KEGG_CYTOKINE_CYTOKINE_ RECEPTOR_INTERAERACTION | 17 | 3.78E-04 | IL1A, IL6R, IL6ST, IL11, LEPR, PRLR, TNFRSF10D, TNFRSF10C, CCL2, CXCL2, CXCL3, BMPR2, TNFRSF9, TNFRSF21, TNFRSF11B, TNFSF14, CD70 |
| KEGG_PHOSPHATIDYLINOSITOL_ SIGNALING_SY_SYSTEM | 9 | 4.51E-04 | PIK3R1, PIP5K1C, PIP5K1A, ITPR1, SYNJ2, INPP5A, OCRL, INPP4B, DGKE |
| BIOCARTA_ARF_PATHWAY | 5 | 4.79E-04 | RB1, ABL1, PIK3R1, RAC1, POLR1A |
| KEGG_SMALL_CELL_LUNG_CANCER | 9 | 7.38E-04 | RB1, CDK6, SKP2, PIK3R1, AKT3, ITGA6, FN1, LAMB2, MAX |
| KEGG_CHRONIC_MYELOID_LEUKEMIA | 8 | 1.66E-03 | RB1, ABL1, CDK6, CBL, CBLB, PIK3R1, AKT3, RUNX1 |
| KEGG_FOCAL_ADHESION | 13 | 1.93E-03 | PIK3R1, RAC1, AKT3, ITGA6, FN1, LAMB2, MAPK8, PIP5K1C, ELK1, THBS1, ARHGAP5, COL1A1, COL5A2 |
| KEGG_GNRH_SIGNALING_PATHWAY | 9 | 2.05E-03 | MAPK8, MMP2, ITPR1, ELK1, MAP2K4, ADCY8, ADCY7, ADCY6, GNA11 |