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. 2016 Sep 20;36(5):2489–2500. doi: 10.3892/or.2016.5112

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Stratification analysis for efficiency of chemotherapy in stage IIa breast cancer with different expression of SHMT2. In the Kaplan-Meier analysis, all participants in the NKI set were re-stratified as SHMT2-low (Q₁ and Q₂) or SHMT2-high (Q₃ and Q₄) subgroups. The HR represents the relative risk of chemotherapy (yes vs. no). Adj-HR is adjusted HR, the value of HR was adjusted by co-factors including age, hormone therapy, Elson grade and intrinsic molecular subtype. (A) Kaplan-Meier analysis of PFS for chemotherapy on SHMT2-low stage IIa breast cancer subgroup. (B) OS analysis for chemotherapy SHMT2-low stage IIa breast cancer subgroup. (C) PFS analysis for chemotherapy SHMT2-high stage IIa breast cancer subgroup. (D) OS analysis for chemotherapy SHMT2-high stage IIa breast cancer subgroup. (E) Multivariate Cox proportional hazard analysis for chemotherapy at different expression levels of SHMT2 subgroups.