Table I.
Demographic distribution of SHMT2 in breast cancer (ZJU set) patients.
| SHMT2
|
P-valuesb | ||
|---|---|---|---|
| High (%a) | Low (%) | ||
| Age (years) | 0.5442 | ||
| <50 | 49 (76.6) | 15 (23.4) | |
| ≥50 | 46 (71.9) | 18 (28.1) | |
| Histological type | 0.0582 | ||
| Ductal carcinoma | 79 (78.2) | 22 (21.8) | |
| Lobular carcinoma | 9 (50.0) | 5 (50.0) | |
| Other | 6 (75.0) | 2 (25.0) | |
| pT stagec | 0.0203 | ||
| T0–1 | 21 (60.0) | 14 (40.0) | |
| T2–4 | 71 (80.1) | 17 (19.9) | |
| pN stagec | 0.0175 | ||
| 0 | 39 (63.9) | 22 (36.1) | |
| 1–3 | 42 (80.8) | 10 (19.2) | |
| >3 | 14 (93.3) | 1 (6.7) | |
| Grade | 0.0067 | ||
| 1, Well | 8 (66.7) | 4 (33.3) | |
| 2, Mod | 27 (60.0) | 18 (40.0) | |
| 3, Poor | 47 (87.0) | 7 (13.0) | |
| ER | 0.3225 | ||
| Negative | 36 (78.3) | 10 (21.7) | |
| Positive | 44 (69.8) | 19 (30.2) | |
| PR | 0.1004 | ||
| Negative | 43 (81.1) | 10 (18.9) | |
| Positive | 37 (67.3) | 18 (32.7) | |
| HER2 | 0.2964 | ||
| Negative | 66 (73.3) | 24 (26.7) | |
| Positive | 20 (75.4) | 4 (24.6) | |
| MKI67 | 0.0179 | ||
| Negative | 26 (61.0) | 16 (39.0) | |
| Positive | 56 (82.3) | 12 (17.7) | |
| Molecular subtype | 0.5496 | ||
| Luminal A | 20 (75.0) | 12 (25.0) | |
| Luminal B/HER2− | 20 (80.0) | 5 (20.0) | |
| Luminal B/HER2+ | 6 (75.0) | 2 (25.0) | |
| Basal-like TNBC | 15 (83.3) | 3 (16.7) | |
| HER2-positive | 10 (83.3) | 2 (16.7) | |
| CD44/CD24 status | 0.4380 | ||
| CD44+/CD24− | 37 (71.1) | 15 (28.9) | |
| Other | 40 (74.0) | 10 (26.0) | |
SHMT2, serine hydroxylmethyltransferase 2; ER, estrogen receptor; PR; progesterone receptor. There are 1, 5, 17, 9, 20, 14, 18, 29 and 1 missing cases in histological type, pT stage, grade, ER, PR, HER2, MKI67, molecular subtype and CD44/CD24 status. The classification of molecular types was based on ref. 11.
a
% represents positive rate of SHMT2 _High equal to NHigh/(NHigh + NLow) × 100%.
b
p-values were based on Pearson's Chi-square test.
c
pT and pN stages are pathological tumor and lymph node stages. In pT stage, T0, T1, T2 and T4 represent tumor stage of breast cancer. In pN stage, the number represent how many lymph nodes are involved.