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. 2016 Sep 20;36(5):2489–2500. doi: 10.3892/or.2016.5112

Table III.

Univariate and multivariate analyses for SHMT2 and survival microarray datasets.

Dataset Overall survival
Progression-free survival
HR
(95% CI)		 Adjusted HR
(95% CI)a 		HR
(95% CI)		 Adjusted HR
(95% CI)a
Desmedt
 Q1 Reference Reference Reference Reference
 Q2 0.73 (0.33–1.57) 0.70 (0.31–1.51) 1.13 (0.63–2.05) 1.08 (0.59–2.07)
 Q3 0.80 (0.36–1.70) 0.69 (0.30–1.53) 1.16 (0.64–2.11) 1.30 (0.70–2.40)
 Q4 1.52 (0.78–3.03) 1.21 (0.57–2.59) 1.48 (0.83–2.66) 1.60 (0.86–2.99)
Pawitan
 Q1 Reference Reference Reference Reference
 Q2 3.06 (1.04–11.05)b 2.51 (0.81–9.32) 3.79 (1.16–16.94)b 3.90 (1.19–17.44)b
 Q3 2.82 (0.94–10.31) 2.07 (0.64–7.88) 3.06 (0.88–13.96) 2.25 (0.61–10.56)
 Q4 4.38 (1.58–15.36)c 2.78 (0.96–10.12) 8.26 (2.81–35.20)c 5.29 (1.73–23.03)c
Wang
 Q1 N/A N/A Reference Reference
 Q2 N/A N/A 1.27 (0.73–2.22) 1.28 (0.74–2.24)
 Q3 N/A N/A 0.91 (0.51–1.62) 0.93 (0.52–1.67)
 Q4 N/A N/A 1.81 (1.08–3.09)b 1.91 (1.11–3.33)b
Ivshina
 Q1 N/A N/A Reference Reference
 Q2 N/A N/A 1.31 (0.65–2.76) 1.37 (0.67–2.97)
 Q3 N/A N/A 2.20 (1.14–4.51)b 2.11 (1.07–4.46)b
 Q4 N/A N/A 2.72 (1.43–5.53)c 2.49 (1.23–5.38)b
NKI
 Q1 Reference Reference Reference Reference
 Q2 3.26 (1.45–8.27)c 3.18 (1.42–8.07)c 2.03 (1.13–3.75)b 2.04 (1.14–3.77)b
 Q3 3.74 (1.69–9.43)c 2.75 (1.21–7.04)b 2.32 (1.31–4.27)c 1.91 (1.06–3.58)b
 Q4 4.81 (2.22–11.97)c 2.79 (1.24–7.11)c 2.64 (1.51–4.87)c 1.94 (1.07–3.63)b
Pooled
 Q1 Reference Reference Reference Reference
 Q2 1.71 (1.07–2.80)b 1.28 (0.75–2.22) 1.46 (1.10–1.97)c 1.31 (0.91–1.89)
 Q3 1.85 (1.15–3.02)b 1.30 (0.76–2.26) 1.55 (1.17–2.08)c 1.63 (1.15–2.34)c
 Q4 2.82 (1.81–4.51)c 1.47 (0.86–2.56) 2.26 (1.72–3.00)c 1.75 (1.21–2.56)c

Univariate and multivariate analyses were conducted to evaluate HR of SHMT2. Here, Q1, Q2, Q3 and Q4 represent mRNA expression levels of SHMT2. The detail of grouping is described Materials and methods.

a

For multivariate analysis, HR was adjusted by age, ER status, and Elston grade in the Desmedt set; HR was adjusted by age in the Ivshina datasets. In the Pawitan set, HR was adjusted by Elston grade, and ER and HER2 status. For the Wang set, HR was adjusted by ER status. The NKI set was adjusted by age and grade, ER, tumor size and lymph node status. HR was adjusted by age, ER status and Elston grade in the pool analysis.

b

Statistical significance, p<0.05;

c

Statistical significance, p<0.01. SHMT2, serine hydroxylmethyltransferase 2; HR, proportional hazard ratio; 95% CI, 95% confidence interval.