Fig 3. Tumour-homing of the ⁶⁸Ga and ¹¹¹In -labelled DOTA-peptide WHWRLPS compared to ¹²⁴I-MIBG.

A) The WHWRLPS-DOTA peptide was labelled with ¹¹¹In and i.v. injected into mice (n = 3) bearing xenografts induced by s.c. injection of IMR32 cells. Mice were sacrificed at indicated time-points, tumours and organs were explanted and their activity concentration measured. Results are presented as mean values ± SEM. B) Tumour/blood ratio (black bars) and tumour/muscle ratio (white bars) of ¹¹¹In- labelled WHWRLPS peptide using the data obtained in 3A, p.i. = post injection. C) The ⁶⁸Ga- or ¹¹¹In-labelled WHWRLPS-DOTA peptides (black bars and grey bars, respectively) were injected i.v. in IMR32 tumour-bearing mice (n = 3). As a control, ¹²⁴I -MIBG (white bars) was administered to two mice. Mice were sacrificed after one hour, the tumour and the organs were explanted and their activity concentration was quantified. Results are presented as mean values ± SEM.