Fig 4. PET imaging of tumour using the ⁶⁸Ga -labelled DOTA-peptide WHWRLPS.

A) For kidney protection, a mixture of Gelofundine, lysine and arginine was i.v. injected in tumour-bearing mice prior to i.v. injection of the ⁶⁸Ga-labelled WHWRLPS peptide. After one hour, mice were sacrificed, tumours and organs were explanted and their radioactive content was quantified. All values were corrected for tissue weight and radioactive decay. Results are presented as mean values ± SEM (black bars: no kidney protection, white bars: with kidney protection as described above). B)-D) The ⁶⁸Ga-labelled WHWRLPS peptide was i.v. injected in IMR32 tumour-bearing mice. After one hour, peptides were detected using a PET/MRT scanner. B) PET image, C) MRI image and D) merge of B) and C).